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Old 03-24-2008, 08:53 AM   #1 (permalink)
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Anti depressants

I am going to make an appointment to see my GP this week to change my medication. My depression has been more troublesome these past couple of months and I have seen no improvement since increasing my medication.
I am currently taking 60 mgs of Celexa (citalopram). About 3 weeks ago, my doc added 150 mgs of Wellbutrin due to my symptoms, but I found that this mix just made me agitated so I stopped taking the Wellbutrin after a couple of weeks.
I have been reading online about different SSRI's, and wish to make an informed decision before trying something new. I could see a pdoc again but didn't have good experiences in the past and prefer to approach my GP instead. She's pretty open-minded if I go to her and ask to try something else.
I am hoping that others here can share their own experiences with antidepressants. What do you take? SSRI? MAOI? Tricylic? I've only ever taken SSRI's, although very briefly, years ago, I tried desipramine for a very short time but found side effects troublesome.
I have tried Celexa, Wellbutrin, Zoloft, Lexapro (I think), Effexor, and the only one that worked long-term for me was Celexa. It's just not doing it for me this time. I have been plagued with suicidal thoughts again, and am finding it increasingly difficult to participate in recovery or get out of bed.

I am a 40 year old woman with no significant health concerns except for the depression and mild hypothyroidism. I just had bloodwork done for my thyroid and am awaiting results. I have been sober over 2 years, and clean for 20 months. I have been in recovery for nearly 7 years and relapsed briefly each time after two years.

I have been using a broad-spectrum light every morning for 40-60 minutes, with little or no results.

Please note, I am not looking for medical advice, I just want to hear your experiences in this area, and wish to know what works for you. I want to make a fully imformed decision before seeing my doctor.

Thanks
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Old 03-24-2008, 09:12 AM   #2 (permalink)
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Rowan, I am so sorry to hear that you are in so much pain right now. I pray that you and your doctors will find what works for you.
In my case I was diagnosed with chronic depression, anxiety dissorder and social dissorder. I take wellbutrin, prozac and ativan. I have been on this combination for some time and it seems to work for me. I do however go through my highs and lows, but not to severely. When I am feeling a bit on the manic or agitated side I take an extra ativan.
There is probably something out there that would work better, but I dont want to take a chance on it. If it's not broke why try and fix it.

Best Wishes
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Old 03-24-2008, 09:13 AM   #3 (permalink)
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I started taking Topamax for my anxiety this year, and found it very helpful. It's used off label for that purpose and also for depression off label.

I also started back on Wellbutrin, but, the generic version, buprion. I'm on 200 mg. This morning, I started thinking I was feeling good. It's the first time in a long time. I don't know yet, for sure. Time will tell. I know at 300 mg, it gave me panic attacks. The pdoc wanted me to go up to 300 mg, and I didn't want to for that reason. She agreed to wait untill I see her next month. So, we'll see.

I did not do well on SSRI's. Serotonin Syndrome. I never want to take them again.

One thing I want to suggest. You didn't stay on the Wellbutrin very long. Sometimes, it takes time to "settle into" a new anti depressant. It takes between 4-8 weeks for the theraputic dose for Wellbutrin to reach it's potential. I hope you didn't stop before it settled down for you. Just a thought. I know when I first started taking it, there's kind of a "rush" but, it does calm down in time.

Hope you feel better soon.

Shalom!
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Old 03-24-2008, 09:50 AM   #4 (permalink)
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Thanks to both. Teach, I have been on combo of Wellbutrin and Celexa before, long term, and it wasn't a great mix then, that's why I came off it so quickly this time. Maybe I could have given it more time, but it really didn't feel right for me.
I've been reading about serotonin syndrome and have been wondering if it's time to try an entirely different class of a/d.
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Old 03-24-2008, 09:57 AM   #5 (permalink)
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I am sorry you are going through a rough stretch right now.

It is amazing how much a thyroid can affect depression. My s/o has an underactive thyroid. Depression is significantly worse, to the point of suicidal thoughts when the thyroid is out of wack. Has a very thin line of the normal range. Even when by the standards it is considered in the normal range she still needs it adjusted as her range is very fine. She finally has a doctor that understands that and works with her, listening to her when she says the meds need adjusting up or down.

Here is my experience with anti-depressants I have been on paxil, lexpro, prozac, welbutrin, and Cymbalta. Currently on Cymbalta and it is working wonderfully for me. It has treated my depression quite well. Now if only the PTSD treatment was that effective so the anxiety would go away I would be doing great. But the anxiety is miserable at times. Cymbalta has not seemed to have much effect on the anxiety. I have klonopin to take for that.

You are such an asset here at SR. I am glad you are here. You are one of the first people to welcome me here and talk to me. I really appreciate that. Hang in there as this too will pass as frustrating as that may be to hear, from experience I am sure inside you know it to be true even if it is hard to see through the darkness right now. We have all been in that place. When it gets really rough remember and picture that we are right here with our hands reaching out to you to help you back up. Take care. You are worth the effort it takes to get the medicines right.

Judith
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Old 03-24-2008, 10:45 AM   #6 (permalink)
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(((Ro))) my friend, I'm sorry to hear you're having some difficulties.

I had a looooooooooong reply to this, and of course when I went to submit it our lurvely website asked me to register as a new user and my post was lost That was a nice reminder to save my lengthy posts somewhere else and maybe my HP's way of telling me to keep it short and simple!

If I could just share two very important things I learned from SSRI's:

1. As historyteach mentioned, it can take a long time for them to become fully effective. Lexapro and Zoloft made me immediately suicidal, Paxil worked like a dream but I was told I couldn't stay on it because it can be addictive, so I finally settled in with EffexorXR. For the first six weeks I felt like I lived in a foggy, distorted haze. I could barely function at work, and I preferred lying in bed or on the couch in absolute silence to doing something productive. When it finally started to take effect I felt amazing, and after slightly more than a year I weaned off of it with no side effects.

2. This is the most important thing I learned. SSRI's were only as effective as my mental well-being allowed them to be. By that I mean that if my outlook and attitude was positive and healthy the Effexor worked beautifully. My instinct was to isolate and be miserable, but I found that I felt best when I was doing something outdoors, even something as simple as sitting at an outdoor cafe, sipping coffee and watching the world go by was an incredible feeling. And while there were times when I still felt suicidal, I found that going to a recovery meeting or diving into service work always relieved me of those feelings. Being around as many people as possible helped too, and of course others in recovery understood me best.

In early recovery and before I started taking the meds I felt like Winnie The Pooh walking around with a black rain cloud over my head. Life felt dark, miserable, and unbearable. Nobody deserves to live like that, I hope you find something that works for you soon.

Scott
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Old 03-24-2008, 12:02 PM   #7 (permalink)
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First of all, I just want to make clear that my medications aren't the solution to all my problems, but they help me live a relatively normal life while I work a program of recovery.

I've been through the gamut with antidepressants over the past 15+ years. I started on Cymbalta about 7 months ago.

In addition to my 12 step meetings, I started back in some counseling at the local mental health center shortly before Christmas.

I was doing everything possible within my recovery, yet my depression continued to deepen.

I did request a medication evaluation with a psychiatrist at the mental health center as my meds were always through my primary care physician.

I am currently on Cymbalta, 90 mg (up from 60), and Remeron (15mg) was also added to help with sleep and weight gain (I had dropped 16 pounds when the depression hit hard).

It appears to be working. I still attend my 12 step meetings on a regular basis, and stay active in my recovery. I was seeing the counselor every other week but am now down to once a month
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Old 03-24-2008, 12:44 PM   #8 (permalink)
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Rowan,
I used antidepressants off and on during my thirties and early forties, basically for PMS symptoms and they worked great. Back then that treatment was unheard of and scoffed at. I used low doses and for half of the month. Once in while I used xanax...usually one pill per month.

Over several years my drs & I tried just about everything else in order to give me the best care. I prefer good old Prozac and/or Zoloft, and my mood would improve in a day or two and continue to improve for up to two weeks.

Although the research does not back this up...many women- including me have extreme problems with hormone levels. For this reason my dr gave me oral (rxs) and topical (otc)progesterone and as my needs evolved I ended up using a micronized progesterone in the form of a birth control pill!

I had frequent blood tests done to examine the hormonal balance and for about a year I used bioidenticals formulated just for my needs. It may sound complicated but I am condensing about 15 years of my history here.

I was very fortunate to have a GP and GYN who were willing to experiment and treat me a person instead prescribing some cookie cutter treatment. (I was a good guinea pig for them!)

So basically...only if my moods got to the point where things got scary for me did I use anti-d's and the last time I tried one...it did absolutely nothing for me. I later found relief by using HRT, but not the kind that was used in the Framingham studies and found to be harmful.

Of course this is just my individual example but I do know of many women-where finding hormonal balance is key to having stable moods. And one thing that I always did was to stay under the care of a physician (or two) instead of diagnosing and treating things myself with the natural progesterone cream that I used. It's funny that the name on the label of that cream included the word "happy" which was not false advertising!!

Good luck and I hope you find a way to feel your very best, soon.
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Old 03-24-2008, 01:34 PM   #9 (permalink)
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I had found an alternative therapies M.D. in another city a couple of years ago who had prescribed HRT for my symptoms. He had prescribed bioidentical progresterone cream, and it helped some, but not significantly. My PMS used to be horrible, but it's not as bad now for some reason. When I was seeing this particular doctor, he ordered bloodwork regularly and is the one who started me on thyroid medication - I was like the person Judith mentioned who walked a very fine line within the normal range.
I stopped seeing that doctor due to distance and due to finances. He isn't covered by provincial insurance and I couldn't afford to keep seeing him. If I had a lot more money, I would be interested in continuing to see him, as I liked his whole-body approach.
While I understand that the proper medication will help, it won't cure me. I know I need to attend meetings regularly, to get out among people, to sit in the sun and to walk my dogs. But without the right medication, I don't feel I have sufficient strength to even do these things.
I went to a meeting with my sponsor last night, and saw a bunch of friends, but I sat in the back and distanced myself from most. It was very difficult to be out, but I will go out again tonight, and I will go to work in the morning. I feel like I am moving underwater, and I am mired in shame and guilt for not doing more, not doing better. I am home with my 12 year old daughter and we spend a lot of time together, even lying in bed watching a movie or television program, but I feel like a failure for not being more.
I still can't shake my father's voice telling me to get up and get moving. He makes it sound so sensible. Just do it, right? So I get up and I shower and I'm clean but I'm tired and I need to lie down again. Or, I'll go out, but the sun will hurt and noises are too loud and traffic frightens me and I want to come home again.
My parents are in Florida until the beginning of May and I don't want them to come home. My dad is so intrusive, and then he will find out about my boyfriend, and I'll have to talk to him about that. And I don't want to. It's easier to disentangle myself from him when he's not here - I just don't answer the phone. But soon he will be able to drop by again.
My job ends on Friday - it was a mat leave position - I don't know where I will go next but the uncertainty has left me paralyzed. I want to just .. disappear.
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Old 03-24-2008, 01:51 PM   #10 (permalink)
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Originally Posted by Rowan View Post
I know I need to attend meetings regularly, to get out among people, to sit in the sun and to walk my dogs. But without the right medication, I don't feel I have sufficient strength to even do these things.
I went to a meeting with my sponsor last night, and saw a bunch of friends, but I sat in the back and distanced myself from most. It was very difficult to be out, but I will go out again tonight, and I will go to work in the morning. I feel like I am moving underwater, and I am mired in shame and guilt for not doing more, not doing better. I am home with my 12 year old daughter and we spend a lot of time together, even lying in bed watching a movie or television program, but I feel like a failure for not being more.
I still can't shake my father's voice telling me to get up and get moving. He makes it sound so sensible. Just do it, right? So I get up and I shower and I'm clean but I'm tired and I need to lie down again. Or, I'll go out, but the sun will hurt and noises are too loud and traffic frightens me and I want to come home again.
I hate to think I'd sound like anyone's father, and I feel like an idiot thinking that it's so simple because I know it's not, but there are still times when I have to force myself to "just do it".

For a few months I plopped my kids in front of a TV with a frozen meal while I laid in bed and stared at the ceiling. I still have guilt over that, I felt like I was ignoring them.

During that time I also had problems with taking care of myself. I didn't want to shave, shower, eat right, put on deodorant, anything. I just didn't give a crap about myself. But every morning I put one foot in front of the other, took a shower, did the best I could, and somehow made it through every day. I guess it was my version of "suiting up and showing up". I still think about how I thought I'd feel like that forever, but if it hadn't passed I wouldn't be here posting this.

I'm pretty impressed with your thought patterns, you're a lot stronger than I was Ro! Please don't disappear, I know there's a lot of people who admire your recovery. I know I sure do!
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Old 03-24-2008, 02:21 PM   #11 (permalink)
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{{{Ro}}}
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Old 03-24-2008, 02:26 PM   #12 (permalink)
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In early recovery and before I started taking the meds I felt like Winnie The Pooh walking around with a black rain cloud over my head. Life felt dark, miserable, and unbearable. Nobody deserves to live like that, I hope you find something that works for you soon.
Couldn't resist the chance to tease you a little here. It was Eyore that was the one with the cloud hanging over his head. I only know this because he was the character I identified with for many years. I still love the character because he reminds me of who I have been and who I still can be.
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Old 03-24-2008, 02:29 PM   #13 (permalink)
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Couldn't resist the chance to tease you a little here. It was Eyore that was the one with the cloud hanging over his head. I only know this because he was the character I identified with for many years. I still love the character because he reminds me of who I have been and who I still can be.
I stand corrected! Thanks Judith;-) Ya see, the fog still hasn't lifted for me yet!
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Old 03-24-2008, 02:35 PM   #14 (permalink)
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Eeyore - of course. I kept trying to envision Pooh bear with the rain cloud and it wasn't working - I was a big Winnie the Pooh fan (my uncle called me Pooh) and was sitting here, unable to make the connection. Brain fog. Urgh.
Ah Scott, I do understand what you mean about suiting up and showing up and that's what I will do. But it hurts so much.
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Old 03-24-2008, 02:36 PM   #15 (permalink)
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