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I haven't heard anything about Wellbutrin specifically.
For me though...when I was on Effexor for a year it seemed to totally loose all effectiveness on me. I went off in and spent about 6 months to a year off it, but nothing seemed even close to effective....that was until I went BACK onto the Effexor and added Wellbutrin to the mix.
So maybe my body/mind needed a little break from the med to start working again? Or maybe the Effexor isn't doing anything for me and it's all the Wellbutrin working so well? Or maybe my major depression just naturally ended (or coming to an end).
I don't know. There seems to be so many variables to consider about EVERYTHING. Who can really know for sure? But I have heard that many loose their effectiveness over time...but that's about all I've heard or read.
Sorry..
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