Hi, I haven't gone from Zoloft to Wellbutrin.But I do know that they are different types of antidepressants. They deal with different brain transmitters. I am no expert on this at all-just going by what I've read. If you are on an SSRI, as long as it affects the same brain chemical and you stay at the same dose-you should be able to switch with no real problems. Since Wellbutrin is different than Zoloft, I'm not sure what to do there.
Here's from
www.crazymeds.org under All About Antidepressants:
"If you do have to switch meds because of either poop-out or adverse effects, or it just wasn't the right neurotransmitter, keep in mind that mileage may vary considerably. Sometimes you won't notice a thing, say if you move between Celexa (citalopram hydrobromide) and either Lexapro (escitalopram oxalate) and Prozac (fluoxetine hydrochloride), just as long as the dosages are in line. But with other meds, especially if you're crossing the boundary of neurotransmitters, you'll run into all sorts of fun as your brain adjusts to the switch. If you do change from a med that works on one neurotransmitter to another, it's best to get completely clean of the first med before starting the next, otherwise you'll risk the side effects of a new med on top of the side effects of discontinuing an old med. "
Hopefully someone with experience will answer. Good luck.