I know for sure that if you are being treated for depression you should not take melatonin.
I can't take it with or without other meds, it makes me groggy and my head doesn't clear up when I wake up sometimes for the whole day. Makes me spacey.
We are all different. I just know it is not for me.
I think if you read the label it says do not take this if you have depression or are being treated for depression. Or maybe I looked that up on the web. Because I always look things up. But I think it is on the label.