[junem]

Here is some more info

Therapeutic class: ANTIDEPRESSANTS
Drug Alert
October 15, 2004:FDA Issues Public Health Advisory for Antidepressant Use in Children and Adolescents
June 30, 2004:Venlafaxine Associated With Neonatal Complications
March 22, 2004:Antidepressants May Cause Depression and Suicidality - 10

Dosage and Uses

Adult Min/Max Dose: 37.5mg/225.0mg

Common Dosages by Indication:
Depression take 1 capsule (37.5mg) by oral route once daily with food
take 2 capsules (75mg) by oral route once daily with food
take 1 capsule (75mg) by oral route once daily with food
take 2 capsules (150mg) by oral route once daily with food
take 3 capsules (225mg) by oral route once daily with food
take 1 capsule (150mg) by oral route once daily with food
Generalized Anxiety Disorder take 1 capsule (37.5mg) by oral route once daily with food
take 2 capsules (75mg) by oral route once daily with food
take 1 capsule (75mg) by oral route once daily with food
take 2 capsules (150mg) by oral route once daily with food
take 3 capsules (225mg) by oral route once daily with food
take 1 capsule (150mg) by oral route once daily with food
Social Phobia take 1 capsule (37.5mg) by oral route once daily with food
take 2 capsules (75mg) by oral route once daily with food
take 1 capsule (75mg) by oral route once daily with food
take 2 capsules (150mg) by oral route once daily with food
take 1 capsule (150mg) by oral route once daily with food


All Labeled Uses: Depression, Generalized Anxiety Disorder, Social Phobia
Unlabeled Uses: Depression associated with Manic Depressive Disorder
Drug-Drug Interactions

Contraindicated Drug Combination:
Clearly contraindicated in all cases and should not be dispensed or administered to the same patient:
SEROTONIN REUPTAKE INHIBITORS/MAOI'S - Adverse reaction with both drugs
QT PROLONGATING AGENTS/DROPERIDOL - Adverse reaction with both drugs
QT PROLONGATING AGENTS/LEVOMETHADYL - Adverse reaction with both drugs
QT PROLONGATING AGENTS/SPARFLOXACIN - Adverse reaction with both drugs
QT PROLONGATING AGENTS/HALOFANTRINE - Adverse reaction with both drugs
QT PROLONGATING AGENTS/PIMOZIDE - Adverse reaction with both drugs
QT PROLONGATING AGENTS/MESORIDAZINE - Adverse reaction with both drugs
QT PROLONGATING AGENTS/BEPRIDIL - Adverse reaction with both drugs
QT PROLONGATING AGENTS/THIORIDAZINE - Adverse reaction with both drugs
SEROTONINERGIC AGENTS/DEXFENFLURAMINE; FENFLURAMINE - Adverse reaction with both drugs

Severe Interaction:
Action is required to reduce the risk of severe adverse interaction.
SEROTONINERGIC AGENTS/SIBUTRAMINE - Adverse reaction of the latter drug

Moderate Interaction:
Assess the risk to the patient and take action as needed.
QT PROLONGATING AGENTS/METHADONE - Additive side effects from both drugs
QT PROLONGATING AGENTS/APOMORPHINE - Additive side effects from both drugs
SSRI'S; SSNRI'S; VENLAFAXINE/AMPHETAMINES - Adverse reaction with both drugs
QT PROLONGATING AGENTS/PROPAFENONE - Additive side effects from both drugs
QT PROLONGATION AGENTS/DOLASETRON - Additive side effects from both drugs
QT PROLONGATION AGNETS/RISPERIDONE - Additive side effects from both drugs
QT PROLONGATION AGENTS/SOTALOL - Additive side effects from both drugs
QT PROLONGATION AGENTS/MOXIFLOXACIN - Additive side effects from both drugs
QT PROLONGATION AGNETS/GATIFLOXACIN - Additive side effects from both drugs
QT PROLONGATION AGENTS/DOFETILIDE - Additive side effects from both drugs
QT PROLONGATION AGENTS/ARSENIC - Additive side effects from both drugs
QT PROLONGATION AGENTS/AMIODARONE - Additive side effects from both drugs
ANTIDEPRESSANTS/BUPROPION - Additive side effects from both drugs
SSRI'S; VENLAFAXINE/LITHIUM - Adverse reaction with both drugs

Label Warnings

Pediatric
Relative Contraindication: POSSIBLE INCR. SUICIDAL IDEATION & ATTEMPT IN PEDS. W/MAJOR DEPRESSION

Lactation
Precaution: NO IMMEDIATE EFFECTS OBSERVED IN INFANTS, LONG TERM CNS EFFECTS UNKNOWN.

Pregnancy
Only When Necessary: CAUTION 3RD TRIMESTER, REPORTS INCLUDE NEONATAL RESP DISTRESS,OTHER ADV EFFECTS

Geriatric
Precaution: MAY NEED TO ADJUST DOSE/INCREASED RISK HYPONATREMIA

Adverse Effects

Most Frequent:
Abdominal Pain with Cramps, Accommodation Disorder, Anorexia, Anxiety, Blurred Vision, Chills, Constipation, Diarrhea, Dizziness, Drowsiness, Dysgeusia, Dyspepsia, Flatulence, General Weakness, Headache, Hyperhidrosis, Insomnia, Nausea, Nervousness, Nightmares, Paresthesia, Rhinitis, Sexual Function Impairment, Tremors, Visual Changes, Vomiting, Weight Loss, Xerostomia

Less Frequent:
Acute Confusional State, Chest Pain, Depersonalization, Depression, Dysuria, Emotional Lability, Feeling Agitated, Hypertension, Increased Urinary Frequency, Mental Changes, Mood Changes, Palpitations, Pruritus, Skin Rash, Tachycardia, Tinnitus, Twitching, Urinary Retention

Rare:
Dyspnea, Hypomania, Manic Disorders, Menstrual Disorder, Orthostatic Hypotension, Peripheral Edema, Prolonged QT Interval, Seizure Disorder, Suicidal Ideation, Torsades de Pointes, Trismus

Drug-Disease Contraindications

Significant
Hypertension, Pregnancy, Prolonged QT Interval, Recovery Phase Following Myocardial Infarct, Severe Hepatic Disease, Suicidal Ideation, Upper GI Bleed

Possibly Significant
Blood Coagulation Disorder, CNS Disorder, Congestive Heart Failure, Drug Abuse, Drug Dependence, Epilepsy, Manic Depression