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I don't have experience with the Zoloft, but I'm currently on Effexor XR and it seems to be working pretty well. I had taken Lexapro for almost a year, and it never really did as much as I would have liked for the depression, but was fabulous for anxiety.
I've had some mild side effects with dose increases on the Effexor, but they seem to last a few weeks and get less as time goes on. The biggest side effects I've had are a bit of nausea, foggy brain and some memory issues. It's helping to level out the depression and has given me alot of physical energy back. The biggest downside is that it doesn't help much with anxiety for me. Doc is increasing the dose and I'm on a secondary med to try and address that.
Good luck!
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Success is not final, failure is not fatal: it is the courage to continue that counts. ~ Churchill
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