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Hi Sugarsweetpea,
I have been on both of these medications. I, personally, had a lot more success with Zoloft. My problem was mostly with anxiety though.
Zoloft gave me very few side effects and helped a lot with my anxiety. I may have felt a little lethargic but it was nothing bad.
Effexor increased my anxiety a lot. I actually had to stop taking it because of the side effects. It was also extremely difficult to stop taking. I had some pretty bad withdrawals from it, and I swore I would never take it again.
So that is my experience with these two medicaitons. Remember though that everybody reacts differently.
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