[pedagogue]

There has been some research done in what they call the "poop out" effect in regard to SSRIs (anti-depressants). Basically the meds lose their effectiveness (due to prolonged over-activation) , even at a high dose. IIRC the research found that it can effect a decent portion of people (under 50%, but still somewhere in the double digits), but that doesn't mean it is a 'forever' thing. Typically docs will "cycle off" that med and bring it back later, and use a different class of med in the interim. This obviously will vary by doc, and each case is different, so make sure to talk to your doc about your options.

-p