That's hard...I've been dealing with depression for about 6 years now. I added alcohol into the mix a couple years ago-which didn't help ANYTHING. But I do know when I switched from Prozac to Wellbutrin it dramatically changed my life. I had a rough period while on the Wellbutrin and decided to go off it...I sank into a coma-like state. It was HORRIBLE. I lived on my couch for three months.
I started taking the Wellbutrin again and along with therapy got myself back into working order...then added alcohol and the work I did started crumbling (another story, I know) So I hope that helps. Talk with your/a psychiatrist. That's what they're there for

I wish you the best.